Endocrine Abstracts

The secretion of growth hormone (GH) is under the feedback control of numerous nutritional and endocrine factors. The most widely used endocrine dynamic tests used to diagnose GH deficiency, insulin hypoglycemia test, and glucagon test, are time-consuming and cumbersome both for patients and medical personnel. There is an unmet need for easier to conduct, shorter, and safer diagnostic tests. We and other groups have previously demonstrated that acute administration of glucagon...

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a popular tool for the treatment of type 2 diabetes. Unlike many other antidiabetic drug classes, distinct GLP-1 RAs have different therapeutic profiles, mostly due to their different pharmacokinetic properties. Animal experiments and human data indicate that tolerance develops toward at least some of their effects, e.g., gastric motility. Whether tolerance develops toward the glucose-lowering effect...